A positive HPVhigh-risk test indicates that the patient may be infected with HPV genotypes (16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 60, 68, 73, 82) which are associated with cervical cancer and precursor lesions thereof. Mixed infections with other genotypes may occur; the results should always be correlated with cytology.
A positive low-risk HPV (6, 11, 40, 42,43, 44, 57, 61, 70, 72, 81) indicates lesions associated with condylomata. The HPV typing is conceived for its use as a complementary test and in no case as a single diagnostic criterion; therefore, in conjunction with cytological and histological studies, it is very effective in predicting the progression of cervical lesions, differentiating those that mean a high risk of those involving a low risk in relation to cancer. Carefully analyze a negative result, may be caused by a poorly drawn sample or with DNA below the detection limit of the test. The HPV screening test is aimed at women and men primarily once they initiate their active sex life, and should be repeated periodically, especially if they frequently change partners. The high sensitivity and specificity of the PCR makes possible the detection and typing of the virus at a very early stage of infection even though there are still no cytological abnormalities; in infected patients, it is important to perform colposcopy-directed cytological tests where possible. The HPV screening test should be integrated into the classic arsenal of Pathological Anatomy labs to facilitate the management of cases with lesions that are difficult to classify histologically.